Salmonella is a major causative organism of gastroenteritis in humans worldwide, and most cases are caused by the consumption of raw or undercooked poultry products. In response to public concern, many countries have introduced survey and control programmes for Salmonella in poultry. However, it remains an economic burden in many areas, and there are emerging risks associated with new serovars. In this chapter, we describe the invasion and transmission mechanisms of Salmonella, review the currently available detection methods and then provide a detailed overview of the strategies available for controlling Salmonella in poultry, with a particular focus on those employed before the meat is harvested.