Salmonella infections of zoonotic origin are one of the most frequent causes of zoonotic infections worldwide, and there are clear indications that, at least in some countries, pork is an important source of human salmonellosis. This chapter describes the epidemiology of salmonella and possible interventions in the pig and pork production chain. The chapter addresses animal surveillance and monitoring, control of feed and environment, and the importance of replacement animals and finisher herds. The chapter also considers vaccination as a reduction strategy and measures that can be adopted at the slaughterhouse stage. Including a detailed case study on salmonella reduction in Danish pig and pork production, the chapter offers detailed guidance on further reading in this area.