Hybrid wheat breeding offers great potential to deal with increasing demands for food and feed of future generations. Wheat hybrids possess substantial heterosis for grain yield and can combine disease resistance and quality traits with higher grain yield compared to line cultivars. Moreover, hybrid wheat breeding offers the smart stacking of major dominant genes. Major challenges are the establishment of heterotic groups and the need to increase the cross-pollination capability of wheat for a more efficient hybrid seed production. The chapter describes heterosis in wheat and heterotic groups, before moving on to consider hybrid seed production. Finally, the chapter discusses the relative advantages of hybrid versus line breeding.