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In this book, the editors and chapter authors survey the fundamental principles, advantages, and limitations of using localized surface plasmon resonance to the Raman signal in PERS. They discuss the overall progress in this field and issues that influence the sensitivity and interpretation of these techniques. It will provide an overview of state-of the-art PERS applications in cancer and other diseases, bioanalysis and the study of surfaces and interfaces. This book will also troubleshoot common experimental issues, largely based on clinical experience. Finally, there is a conclusion by examining future directions and issues to be addressed of PERS techniques for clinical applications. It will therefore summarise the recent developments, challenges, opportunities, and limitations with plasmonic platforms coupled with Raman scattering-based optical identification and therapies. Further, it will explore the barriers to acceptance/translation and outline recent progress which may overcome these issues. In summary, this book will directly address, for the first time, all translational aspects, and clinical perspectives of Raman guided disease nanomedicine from a comprehensive and multidisciplinary perception.
Key Features
- Book focuses on the cellular and clinical applications of plasmon-enhanced Raman scattering (PERS) , with special emphasis on the physics, chemistry and design of plasmon structures.
- Practical research studies are incorporated on the mechanisms of action of PERS. The latest developments in deep tissue photosensitization and penetration of plasmonic structures for light-mediated targeted therapies are discussed.
- The novelty of the book is the comprehensive coverage, which not only theoretically explains the latest research on PERS, but also gives an insight into promising targets for human disease
- Incorporation of appropriate videos related to specific clinical applications
- Despite the significant interest and the rapid development of PERS, there is currently no adequate and accessible book on this topic.
Section A
Physics of the Plasmon Enhanced Raman Spectroscopy
Chapter 1: Plasmon enhanced Raman spectroscopy: fundamentals and principles.
Chapter 2: Plasmon enhanced fluoresce and Raman scattering.
Chapter 3: Quantum physics of plasmon-enhanced Raman scattering.
Chapter 4: Spontaneous Raman and plasmon-enhanced Raman scattering.
Section B
Nanomaterials for PERS
Chapter 5: Properties of plasmon surface resonance in nanoparticles.
Chapter 6: Fundamentals of nanomaterials for Plasmon-Enhanced Raman Scattering.
Chapter 7: Plasmonic metal and polymer nanocomposites for Raman Scattering.
Section C
From cells to clinic
Chapter 8: PERS-based studies on living cells and the cellular environment.
Chapter 9: Surface enhanced spatially offset Raman spectroscopy (SESORS) for lesion localization and direct optical feedback.
Chapter 10: PERS as a diagnostic tool for in vitro, in vivo and ex vivo cancer detection.
Chapter 11: PERS in cancer diagnostics.
Chapter 12: Applications of PERS for detection of biomaterials and its advances for COVID-19 investigations.
Chapter 13: PERS for the detection of infectious diseases.
Chapter 14: Development of PERS for use in precision medicine.
Chapter 15: Future of PERS.