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‘The Physics of Cancer Volume 6 (Second edition)’ book focuses on the topics of extracellular vesicular communication of cancer cells with their environment, such as matrix networks and neighbouring cells like immune and stromal cells, the role of autophagy in cancer and the dual function of mast cells in solid tumors in relation on immune regulation and mechanobiology. There is a rich history of the physical sciences contributing to cancer research and treatments, yet there is currently no such book that covers all of the new techniques and developments in the field of the physics of cancer. The purpose of this book is to make these very relevant topics visible to the research field to ensure they receive more attention in the scientific community.
Key Features:
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Sixth volume of the author's 'Physics of Cancer (Second Edition)' books, a highly regarded series.
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Comprises chapters that have been designed as self-contained units.
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Written by a widely respected expert in the physics of cancer field.
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Includes research findings that have been presented in numerous peer-reviewed journal articles.
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Contains extensive references at the end of each chapter to enhance further study.
Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumormicroenvironment mechanics. She has published over 160 referred journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 20 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.
Part 1. Cellular Mechanisms and their Impact on Mechanics Chapter 1 Matrix-Modification by Cells : Exosomes and Cancer
Chapter 2 Endosomes and their Role in Cancer Chapter 3 The Two Faces of Autophagy on Different Time Scales Chapter 4 RNA’s Benefit or Driver of Cancer and Cancer Mechanics Chapter 5 Cancer Stem Cells and their Sorting out of Primary Tumors
Chapter 6 What is the Hallmark of Cancer and is the Number Still Rising?
Chapter 7 Effect of Temperature on Cancer and Cancer Mechanics
Part 2 Genetics-Based and RNA-Based Techniques in Cancer Treatment Chapter 8 CRISPR/Cas System from a Biophysical Perspective
Chapter 9 Optogenetics from a Biophysical Perspective
Chapter 10 RNA’s as Vaccines for Cancer
Preface
Acknowledgements
Author biography
1 Matrix-modification by cells: exosomes and cancer
2 Endosomes and receptor endocytic routes in cancer
3 The two faces of mast cells in cancer from a mechanobiological perspective
4 Apoptosis and the faces of autophagy in cancer on different time scales
5 Mechanobiological aspects of autophagy in cancer and various subtypes of selective autophagy
6 Cancer as a mechanobiological disease: targeting the mechanism of mechanical plasticity and dynamical mechanoregulation
7 The dynamic and adaptive mechanical signature of cancer cells and their molecular biological features regulate their metastatic journey