The targeted use of fungicides can help minimise the yield losses caused to grain cereals by plant pathogenic fungi. However, the long-term use of fungicide classes based on a single mode of action has imposed consistent selection pressures on certain pathogens. Over time, this has resulted in many cases of fungicide resistance, leading to a reduction or the total loss of field performance of a range of active ingredients. There is a pressing need to develop anti-resistance management strategies. This chapter briefly reviews the development of resistance in cereal pathogens, before presenting and evaluating a variety of anti-resistance strategies. We include case studies of how data from field trials have helped to illustrate the impact of different control strategies.