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This book is divided into three sections: 1) Components of exocytotic pathways; 2) Biophysical insights from synthetic and reconstituted systems; and, 3) Physiological systems of exocytosis. The first section begins with a description of how secretory organelles form and are packaged with appropriate constituents for exocytosis. The second includes two chapters on recently published reconstituted systems of SNARE-mediated fusion. The final third of the book summarizes the cellular and molecular mechanisms of exocytosis and its regulation in diverse systems.
This book is a reference for researchers and students in the fields of exocytosis and membrane trafficking who hope to gain a broad understanding of how these processes operate in various cell types. Historical perspectives on exocytosis are also presented and discussed.
Key Features:
- Comprehensive and cohesive molecules-to-systems presentation of key features of secretory pathways.
- Presents a single volume description of exocytosis regulatory mechanisms in many different cell types.
- A number of chapter authors are highly regarded researchers in the field.
- Detailed descriptions are provided of diverse systems of exocytosis including yeast exocytosis and exosomal secretion.
- Incorporates methodologies that are routinely used by biophysicists to study exocytosis and membrane fusion including electrochemistry, electrophysiology, reconstitution assays, and high-resolution fluorescence imaging.
Preface
Acknowledgement
Editor Biography
List of contributors
1. Introduction
Part I Components of exocytotic pathways
2. Biogenesis of secretory granules
3. Exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex assembly, disassembly, and regulation
4. Secretory granule motions adjacent to the plasma membrane and granule membrane protein mobility: implications for exocytosis
5. Fusion pore stability and dynamics
6. Mechanical regulation of exocytosis and endocytosis
7. A dynamin perspective on endocytosis and coupling to exocytosis
Part II Biophysical insights from synthetic and reconstituted systems
8. Understanding the molecular mechanism of fusion pores through reconstruction
9. Pore-spanning membranes: a tool for neuronal fusion investigation
10. Effects of anesthetics on membrane fusion and exocytosis
Part III Physiological systems of exocytosis
11. Exocytosis in yeast: major players and mechanisms
12. Stimulus–secretion coupling in the adrenal medulla
13. Synaptic vesicle dynamics at the calyx of Held and other central synapses
14. Mechanisms of exocytosis in mammalian fertilization
15. Invited review: molecular regulation of multivesicular endosome fusion and exosome secretion