The importance of managing weeds in a grain legume crop is critical for obtaining optimum yield. All grain legumes are relatively poor competitors with weeds and thus are prone to yield reductions when grown in the presence of weeds. This chapter outlines the nature and challenges of weed interference and methods of weed control, as well as offering two detailed case studies. The chapter demonstrates that a combination of practices, such as cultivar selection, planting date, tillage system, in-crop tillage or cultivation, and/or herbicides are needed to increase the likelihood of successful weed control.