In this chapter, understanding and controlling Salmonella in poultry meat is explored. The authors suggest that studies in model systems based on bacteriophage and vaccines could in turn, more generally serve as an invaluable guide for efforts to limit Salmonella and the emergence of resistance in poultry for other interventions not discussed in this review. The chapter then identifies key areas of future research focused on integrating empirical findings with functional genomics, innovative statistical approaches (e.g., structural equation models), and mathematical modeling. This combination of tools will: (1) enable a more complete understanding for managing Salmonella and AMR in poultry while also improving bird health, immunity, and welfare and (2) provide valuable insights to uncover broad-scale patterns in other pathogens and livestock production systems.