Plant tissue culture can be used to speed up the development and deployment of genetically improved genotypes. Research conducted by multiple groups for over 25 years has led to the development of protocols for efficient somatic embryogenesis (SE) of cacao. This chapter provides a synthesis of publically available information and literature describing the research and development activities on cacao tissue culture and of field-test evaluations of SE-derived plants. The chapter also reviews current activities in cacao-producing countries involving adoption and scale-up for large-scale propagation of important genotypes, providing a number of field studies from Africa, Asia and the Americas.