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This book describes the methodology and applications of solid-state NMR spectroscopy to studies of membrane proteins, membrane-active peptides and model biological membranes. As well as structural studies it contains coverage of membrane interactions and molecular motions. Advances in biological solid-state NMR are very pertinent with high-field developments seeing applications in biological membranes and whole cells. Many of the chapter authors and contributors are world-class experts and leaders in the development and application of biological solid-state NMR.
Key Features
- Addresses principles, methods and applications of solid-state NMR methods to biomembrane studies
- Introduction to biological solid-state NMR and applications to biological membranes
- Structure and dynamics of membrane lipids, proteins and peptides
- NMR studies of membrane interactions and molecular motion
Funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through CRC 1423, project number 421152132, subprojects A02 and A04 is acknowledged. The author would like to thank all colleagues at the Department of Chemical Sciences, Tata Institute of Fundamental Research in Mumbai, India, for hosting and supporting him during the lockdown due to the Corona virus outbreak in India. Dr Ulrike Krug is acknowledged for help preparing the figures for this chapter.
GG acknowledges financial support from the Swedish Research Council, Swedish Cancer Foundation, Kempe Foundation, Knut and Alice Wallenberg foundation (“NMR for Life” Programme), SciLifeLab, Swedish National NMR Centre and Umeå Insamlingsstiftelse for medical research. PTW acknowledges financial support from the EPSRC.
This work was supported by the Natural Sciences and Engineering Research Council (NSERC) of Canada (grant RGPIN-2018-06200 to I.M.) and the Centre National de la Recherche Scientifique (UMR 7203 to D.E.W.). A.P. would like to thank the PROTEO network, the Faculty of Science of the Université du Québec à Montréal (UQAM) and the Fonds Québécois de la Recherche sur la Nature et les Technologies for the award of scholarships. I.M. is a member of Ressources Aquatiques Québec (RAQ) and PROTEO research networks.
Our work on peripheral membrane protein studies by ssNMR has been supported by grants from the US National Institutes of Health grants R01 GM113908 and R01 GM121583, and instrument grant S10 1S10RR033477.