Transmission and colonization of poultry pathogens and infectious diseases can be controlled, and the colonization of major zoonotic pathogens in the poultry can be minimized, through better farm safety management, phytosanitary measures and a pre-harvest Hazard Analysis and Critical Control Point (HACCP) system. Such safety management practice can also significantly reduce food safety challenges that are present during post-harvest processing and packaging, improve the microbial quality of poultry products, better protect consumer health and mitigate environmental contamination. Appropriate control of pest and wildlife infiltration and a well-designed, low-stress environment are fundamental to maintaining optimal flock health. Safety training and education of breeders, farmers, suppliers and workers are essential to produce healthy birds while ensuring that poultry farming remains sustainable and economical.