As soon as a high-quality fruit and good yield are achieved, the mango fruit is harvested and the post-harvest-handling venture begins. It is estimated that, from harvest to plate, more than one-third of the fruit yield is lost. The purpose of this chapter is to review existing information and research outcomes in the preservation of fruit quality and reduction of post-harvest damage and loss by adopting suitable technologies and knowledge during post-harvest operation, storage management, transportation and marketing of mango fruit.