Employing a managerial perspective, this chapter explores economically-relevant approaches to evaluate and implement sustained, scalable technologies and practices which can effectively reduce post-harvest loss (PHL). Key issues addressed include: defining appropriate targets and goals; inclusion of economic effects as well as physical losses; adoption of methods which support appropriate investment decisions; and consideration of effective means by which social and public institutions can conduct interventions to reduce PHL which maximize the chance for sustained, scaled adoption.