Plant genetic resources for food and agriculture, a common concern of all countries, are critically important for the sustainable production of the significantly more nutritious food needed to feed an ever-growing population in the face of climate change and other drivers. This entails the translation of the potentials encoded into their genetic blueprints into improved productivities. The relevant international agreements, instruments and mechanisms, which address the conservation, sustainable use and access and benefit-sharing for these resources, are reviewed along with their remarkable contributions to food security and nutrition. The chapter also highlights the state-of-the-art for the scientific and technological methods used to conserve and add value through genetic gains to these resources. Underscoring the importance of collaborations at various scales, we call for continued global coordination and partnerships on the internationally agreed activities for conserving effectively and deriving the most benefits sustainably from these irreplaceable resources.