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This is the fifth volume of the highly regarded ‘Physics of Cancer (Second Edition)’ series, written with the aim of making very important topics in the physics of cancer visible to the research community. This fifth volume deals with biophysical methods. The first chapter presents the traditional NMR techniques and introduces the relatively new MRE technique for the characterization of cancer cells and tissues. The second chapter provides an overview of magnetic tweezer techniques relevant to cell characterization. The third chapter focusses on the magnetic twisting cytometry techniques. The fourth and fifth chapters discuss the cytoskeletal remodeling dynamics from a biological viewpoint and a physical viewpoint, respectively. The optical tweezer is introduced in the sixth chapter and the optical cell stretcher is discussed in the seventh chapter. In the eighth chapter, microfluidics-based high-throughput cell stretching is discussed and the latest developments are presented.
Key Features
- Fifth volume of the author’s ‘Physics of Cancer (Second Edition)’ books, a highly regarded series
- Comprises chapters that have been designed as self-contained units
- Written by a widely respected expert in the physics of cancer field
- Covers state-of-the-art techniques that were developed by the author
- Includes research findings that have been presented in numerous peer-reviewed journal articles
- Contains extensive references at the end of each chapter to enhance further study
Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumormicroenvironment mechanics. She has published over 150 referred journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.
Preface
About the author
Part I Magnetics-based techniques from a physics of cancer perspective
1 Examination of cancer cells and their ambient matrix using NMR and MRE
2 Magnetic tweezer principles, results, and applications in cancer
3 Magnetic twisting cytometry of cancer cells
Part II Laser-based techniques from a cancer-specific perspective
4 Cytoskeletal remodeling dynamics of single normal and cancerous cells from a biological viewpoint
5 Cytoskeletal remodeling dynamics of single normal and cancerous cells from a physical viewpoint
6 Optical tweezers
7 Optical cell stretchers and their findings for cancer-specific issues
8 High-throughput microfluidics-based cell stretching