The main objective in broiler breeder production is to produce fertilized eggs resulting in healthy and robust day-old broiler chicks. Due to the continuing increase in the genetic potential of the offspring and the improved reproduction performance, there is a high need for professional management and poultry health care of broiler breeder flocks. Implementation of strict biosecurity measures in combination with intensive, well-orchestrated vaccination programs must prevent disease challenges for both breeders and offspring. Points of attention during the rearing period are stress factors like necessary feed restriction, flock density, bird handling, transport and vaccination reactions. A good coordination between rearing and laying period in equipment, management, feed strategy and health care is crucial for maximum chick performance. This chapter gives an overview of the diseases, vaccinations and direct and indirect effects of management and nutritional interventions on health and productivity in broiler breeders.