Chemical fungicides are traditionally used to preserve the quality of fruit and vegetables during storage or transportation. However, the global concern about pesticide use and the reduced efficacy of chemicals due to pathogen-resistant strains have gradually led producers to evaluate safer alternatives for controlling postharvest diseases. Several means, such as natural compounds of animal and plant origin, organic and inorganic salts, antagonistic microorganisms and physical means, are among the approaches that have been recently evaluated to manage fruit rots. This chapter reviews these new alternative means and the latest solutions for controlling postharvest diseases in order to provide effective yet eco-friendly solutions for disease management. The chapter is divided into sections on physical agents (UV light treatment, heat treatment, electrolysed water); chemical agents (organic/inorganic salts, chitosan); and biological agents (biocontrol, botanicals). Concluding comments are provided on the current status of alternatives, and the steps needed to favour their entry into the market.