Potatoes are particularly susceptible to attack from nematodes, with around 70 species from 24 genera several different reported. Nematodes reduce the value of the harvested crop by affecting yield, tuber size and marketability or indirectly through the transmission of viruses. After introducing nematodes and nematode pests of potato, this chapter describes quarantine regulations affecting potatoes with regard to nematodes, before outlining techniques of nematode management. Finally, the chapter describes the major nematode pests of potatoes, outlines future trends in research and suggests further reading on the subject.