In order to intensify agricultural productivity while at the same time enhance ecosystem services, it is necessary to evaluate carefully how current weed-management technologies are deployed, including herbicides and herbicide-resistant crops. Herbicide chemistries and herbicide-resistant crops have provided excellent technologies that have resulted in significant changes to the way weeds can be controlled. This chapter highlights several key components that must form the basis for an effective integrated weed-management strategy, including tillage, the importance of understanding weed emergence relative to the crop, critical periods for weed control, crop morphology, row width, nutrient management and crop rotation.