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Ion Channel Gating and Mechanisms
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31 March 2026

Ionic channels are key signaling molecules that support electrical communication throughout the body. As such, these channels are a central focus of active research as it relates to neuroscience, biomedical engineering, computational biology, biophysics, and drug discovery. This book is developed based on materials from a popular course on Ionic Channels of Excitable Membranes at Johns Hopkins University by late Dr. David T. Yue. The book introduces the quantitative framework including key topics from biophysics, stochastic processes, and mathematical models used to understand ion channel function. Development of these topics will provide a deep understanding of the interrelation of ionic channels to a broad range of biological and engineering fields.
Key Features:
- Textbook will feature work out problems and analogies
- Written and compiled by David Yue’s lab members
SCIENCE / Life Sciences / Biophysics
Preface
Acknowledgments
Author biographies
1 Hodgkin–Huxley view of ion channels
2 The big deal about single-channel information
3 Markovian gating as a linear system I
4 Markovian gating as a linear system II
5 Fluctuation analysis of ion-channel gating
6 Gating currents: an alternate view of channel operation