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Ion Channel Gating and Mechanisms

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This book, targeted towards early graduate students, introduces a quantitative framework to understand ion channel function. Key topics covered include mathematical models and stochastic processes.
  • Format:
  • 31 March 2026
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Ionic channels are key signaling molecules that support electrical communication throughout the body. As such, these channels are a central focus of active research as it relates to neuroscience, biomedical engineering, computational biology, biophysics, and drug discovery. This book is developed based on materials from a popular course on Ionic Channels of Excitable Membranes at Johns Hopkins University by late Dr. David T. Yue. The book introduces the quantitative framework including key topics from biophysics, stochastic processes, and mathematical models used to understand ion channel function. Development of these topics will provide a deep understanding of the interrelation of ionic channels to a broad range of biological and engineering fields.

Key Features:

  • Textbook will feature work out problems and analogies
  • Written and compiled by David Yue’s lab members
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Price: £75.00
Pages: 100
Publisher: Institute of Physics Publishing
Imprint: Institute of Physics Publishing
Publication Date: 31 March 2026
Trim Size: 10.00 X 7.00 in
ISBN: 9780750323864
Format: Hardcover
BISACs:

SCIENCE / Life Sciences / Biophysics

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Preface

Acknowledgments

Author biographies

1 Hodgkin–Huxley view of ion channels

2 The big deal about single-channel information

3 Markovian gating as a linear system I

4 Markovian gating as a linear system II

5 Fluctuation analysis of ion-channel gating

6 Gating currents: an alternate view of channel operation