Food Loss and Waste (FLW) represents a paramount challenge due to impacts on the economy of food systems, and to the environment and food security. Halving FLW by 2030 has also become Target 12.3 of the United Nations’ Sustainable Development Goals (SDG). Diagnosis, monitoring and evaluation of instruments for measurement to promote evidence-based interventions are occurring worldwide, but solutions that involve public-private actions can trigger a clearer path towards investment for FLW reduction. Consequently, investment can imprint dynamism to a point where economic development will contribute to positive indicators in employment, productivity and sustainability. This chapter looks at the challenges in reaching FLW targets and the roles of both the private and public sector in FLW reduction. It features case studies from Chile and Costa Rica. The chapter concludes with a look to the way forward in planning, managing and monitoring FLW Public-Private Partnerships.