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Advancement in the field of nanotechnology has revolutionized the field of medicines and pharmaceuticals in the 20th century. The proper use of nanomaterials in medical applications requires a proper understanding of these compounds. This correct understanding, beyond the physical and chemical properties, must also have the correct logic of use. In other words, the strategic use of nanomaterials with applicable perspective can also help to advance research, but if we go forward with the current research perspective that leads to the expansion of inapplicable researches, the intrinsic importance of using these nanomaterials is eliminated.
This book, considering the importance of nanomaterials and their application in medicine, as well as the significant growth of biomaterials in research fields, introduces the variables law (Rabiee's theory) for the implementation of this research and the establishment of a proper strategy. It should be noted that in addition to observing biocompatibility tests for a biomaterial based on existing protocols and standards, the Applicable Compatibility (AC) parameter is also required in accordance with Rabiee's theory. This book is written in accordance with Rabiee's theory and the contents of this book should be evaluated from this perspective.
Chapter 1 Nanomaterials: Concepts Nanomaterials 1.1. Metallic nano particles: 1.2. Liposomes: 1.3. Dendrimers: 1.4. Nanomaterials classifications 1.5. Fabrication methods
Chapter 2 Bioactive nanomaterials 2.1. Polymers as bioactive materials 2.1.1. Non-biodegradable polymers 2.1.2. Biodegradable polymers 2.2. Composites as bioactive materials 2.3. Biodegradable metals as bioactive materials 2.5. Mechanical behavior of bioactive glasses Chapter 3 Bio-Inspired approaches: carbon-based nanomaterials 3. Carbon-based nanomaterials as a therapeutic platform 3.1. Cargo attachment 3.2. Cell targeting 3.3. Cargo delivery 3.4. Non targeted cargo delivery 3.5. Bio-imaging 3.6. Future biomedical challenges
Chapter 4 Nanomaterials and Biomedical applications 4. Nanomaterials and tissue engineering 4.1. Remodeling induces by myocardial infarction 4.2. Remodeling induces by hypertension 4.3. Recent Pharma approaches
Chapter 5 Enzyme-responsive nanomaterials 5.1. Hydrolase-responsive nanomaterials 5.1.1 Protease-responsive nanomaterials 5.1.2 Trypsin–responsive nanomaterials 5.1.3. Elastase-responsive nanomaterials 5.1.4. Lipase responsive nanomaterials 5.1.5. Glycosidase- responsive nanostructures 5.1.5.1. Hyaluronidase-responsive nanostructures 5.1.5.2 Chitosanase-responsive nanomaterials 5.1.5.3 Amylase-responsive nanomaterials 5.1.5.4. Cellulase-responsive nanomaterials 5.1.6 Other hydrolase-responsive nanomaterials 5.2. Oxidoreductase-responsive drug delivery systems 5.2.1. Glucose oxidase 5.2.2. Peroxidase 5.2.3 Azoreductase 5.2.4 Glutathione reductase