Weeds pose a major threat to agriculture and cause crop yield losses in a big way. What needs to be done to counter the threat of weeds? This chapter discusses many measures to tackle the problem of weeds, especially in tomato cultivation. One of the most important is Integrated Weed Management (IWM). IWM combines direct and indirect weed control strategies to effectively tackle the problem of weeds in tomato cultivation. This chapter then looks into the preventive steps to be taken and discusses methods like crop rotation. Chemical weed control is another important aspect. The chapter also presents case studies on how research has been used to improve tomato cultivation in practice.