Wasting food is unsustainable from environmental, economic, social and ethical points of view. Curbing food losses and waste (FLW) amount would improve food chain sustainability and contribute to food security. For that, reducing FLW is one of the targets of the Sustainable Development Goals (SDGs). This chapter highlights the causes of FLW and identifies possible prevention/reduction ways in agricultural production, harvesting, storage, processing, transport, distribution, marketing and consumption. The chapter outlines strategies to prevent/reduce FLW along the supply chain, including investments, good practices, behavioural changes and coordination within the food chain. The chapter makes the case for adopting a ‘systems approach’ to realise the full benefits of FLW reduction. Finally, the chapter looks ahead to future research trends in this area.