This chapter provides an overview of the nutrients needed, quantities of nutrients used and concepts of nutrient management commonly utilized in commercial grain sorghum production. The chapter describes how these concepts can also be applied to subsistence production as practised in much of the developing world where sorghum is grown. The chapter focuses on the management practices and techniques utilized for the essential mineral nutrients commonly observed to be deficient in sorghum production. These include: N, P, K, S, Fe, Mn, Zn and Cl. The chapter will discuss soil and other conditions under which deficiencies may occur; methods to assess nutrient availability and nutrient sources, both chemical fertilizers and also common by-products which can be used as nutrient sources; and preferred methods and time of applications.