Porcine reproductive and respiratory virus (PRRSV) is responsible for serious losses to the global pig industry and is emblematic of the modern infection disease problem. Respiratory disease caused by PRRSV is the result of a complex interaction of the virus with lung macrophages. PRRSV is unique because it is one of the few pathogens in pigs in which genetic approaches are being actively pursued as a mechanism to lessen the impact of the disease. This chapter focuses on two genetic approaches. The first is a marker-selected approach to identify genomic markers associated with disease resistance, a tool commonly applied to finding improvements of pig performance and carcass quality. The result is the identification of a marker linked to an important macrophage antiviral protein, guanylate binding protein 5 (GBP5). The second genetic approach is to prevent PRRSV infection of macrophages through the genetic modification of the PRRSV receptor CD163.
Price: £25.00
Publisher: Burleigh Dodds Science Publishing
Imprint: Burleigh Dodds Science Publishing
Series: Burleigh Dodds Series in Agricultural Science
Publication Date:
31 October 2022
ISBN: 9781801466875
Format: eBook
BISACs:
TECHNOLOGY & ENGINEERING / Agriculture / Animal Husbandry, Animal husbandry, TECHNOLOGY & ENGINEERING / Agriculture / Sustainable Agriculture, Sustainable agriculture
1 Introduction 2 Porcine reproductive and respiratory syndrome and porcine respiratory disease complex 3 The lung macrophage as the target for porcine reproductive and respiratory virus infection 4 CD163: a functional marker for anti-inflammatory M2 macrophages and a receptor for porcine reproductive and respiratory virus 5 The porcine reproductive and respiratory syndrome Host Genetics Consortium and the search for host genes affecting the response to porcine reproductive and respiratory syndrome infection 6 The WUR marker and its association with guanylate binding protein 5 7 The interplay between porcine reproductive and respiratory syndrome virus, M1 and M2 macrophages, CD163 and guanylate binding protein 5 in the onset and recovery from acute respiratory disease 8 Porcine reproductive and respiratory syndrome resistance through modification of CD163
9 Genetic association between the pig genome and porcine circovirus type 2 and swine influenza A virus 10 Conclusion and future trends 11 Where to look for further information 12 References
