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Immunofluorescence is a key diagnostic tool in dermatopathology, and essential in the diagnosis of connective tissue diseases, vasculitis and other cutaneous disorders. The need to interpret the results of immunofluorescence testing, and correlate these with histopathological results, is a key skill required not just of dermatopathologists but also, increasingly, of dermatologists who either read the slides themselves or use a pathology lab or academic referral centre.
Handbook of Direct Immunofluorescence covers not only day-to-day findings but also less common patterns and rarities, and gives information on important diagnostic pitfalls. Each chapter is dedicated to a specific disease and is introduced by concise text that describes the clinical presentation and pathogenesis: then, multiple images show the range of histopathological and immunofluorescence findings associated with the disease in question.
Key points
- Practical, clinically oriented coverage provides invaluable resource for dermato-, oral and general pathologists, as well as dermatologists
- Includes invaluable information on technical aspects (specimen procurement, transportation, etc) as well as guidance on interpreting histopathological and immunofluorescence findings
- Pattern-based approach serves as logical framework for reaching a diagnosis, as well as understanding when to order additional tests and how to recognise nonspecific findings
Douglas Fullen MD
Professor of Pathology & Dermatology, Univ of Michigan, Ann Arbor, USA
May P Chan MD
Associate Prof of Pathology & Dermatology, Univ of Michigan, Ann Arbor, USA
Aleodor A Andea MD
Professor of Pathology & Dermatology, University of Michigan, Ann Arbor, USA
David P Arps MD
Dermatopathologist, Consolidated Pathology Consultants, Libertyville, USA
Section I: Epithelial intercellular staining pattern
Chapter 1 Pemphigus vulgaris
Chapter 2 Pemphigus vegetans
Chapter 3 Pemphigus foliaceus
Chapter 4 Pemphigus herpetiformis
Chapter 5 IgA pemphigus
Chapter 6 IgG/IgA pemphigus
Section II: Epithelial nuclear staining pattern
Chapter 7 Connective tissue diseases
Chapter 8 Chronic ulcerative stomatitis
Section III: Epithelial intercellular and basement membrane zone
staining pattern
Chapter 9 Paraneoplastic pemphigus
Chapter 10 Pemphigus erythematosus
Section IV: Linear basement membrane zone staining pattern
Chapter 11 Bullous pemphigoid
Chapter 12 Mucous membrane pemphigoid (cicatricial pemphigoid)
Chapter 13 Epidermolysis bullosa acquisita
Chapter 14 Bullous lupus erythematosus
Chapter 15 Linear IgA bullous dermatosis
Chapter 16 Pemphigoid gestationis (herpes gestationis)
Chapter 17 Lichen planus pemphigoides
Chapter 18 Anti-p200 pemphigoid
Section V: Granular basement membrane zone staining pattern
Chapter 19 Dermatitis herpetiformis
Chapter 20 Lupus erythematosus
Chapter 21 Nonspecific granular dermoepidermal junction staining
Section VI: Fibrillar basement membrane zone staining pattern
Chapter 22 Lichen planus
Section VII: Cytoid bodies
Chapter 23 Interface dermatitis/mucositis
Section VIII: Granular vascular staining pattern
Chapter 24 Leukocytoclastic vasculitis
Chapter 25 Henoch–Schönlein purpura
Chapter 26 Nonspecific granular vascular staining
Section IX: Smooth vascular staining pattern
Chapter 27 Porphyria cutanea tarda
Chapter 28 Pseudoporphyria
Chapter 29 Nonspecific smooth vascular staining