Genomic Selection evolved as a promising new method to support decision making for plant breeders. This chapter provides a short introduction to genomic prediction and its usefulness as a selection tool. In addition, the chapter highlights some of the most important factors to be considered when implementing and applying genomic selection in research and plant breeding. The chapter focuses on the application of genomic selection in plant breeding and the discussion of some of the advantages and drawbacks of this method. Finally, the chapter looks ahead to future research trends and provides guidance on further reading in this area.