To ensure populations have sufficient, safe, and nutritious food requires a concerted effort that involves politics, economics, farming practices, and enhancement of crops to withstand abiotic and biotic pressures yet remain productive. Keeping pace with population size and stresses imposed by climate change make it critical for plant scientists to have access and the freedom to apply all the tools available for crop improvement. The advent of gene editing increased the options for achieving desired traits and has been shown to be effective across a broad range of species including those in the Solanaceae, which contains some of the most relied upon food crops, such as tomato and potato. Traits related to disease resistance, fruit and tuber quality have been modified and improved through the use of editing in tomato and potato. Application and effectiveness of different editing approaches based on CRISPR/Cas of solanaceous species are outlined in this chapter.