Clonostachys rosea is a fungal biocontrol agent able to control a range of impactful plant diseases, such as damping-off, root rot, botrytis blight, fusarium head blight, and others. The use of C. rosea can subsequently replace or reduce the use of chemical pesticides. However, biocontrol efficacy can be highly variable depending on factors such as the environmental conditions and the genotypes of the pathogen, host plant, and biocontrol agent. C. rosea can be applied through seed treatment, drenches, sprays, pollinators, and in combination with other biocontrol agents, depending on the disease being targeted for management. While C. rosea was first characterized as a mycoparasite, it can also act through other mechanisms to control disease such as the secretion of cell wall degrading enzymes, antibiosis, endophytic colonization and the induction of plant defenses. Clonostachys rosea also has the potential to control other plant pests, such as nematodes or insects.