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Deconstructing Psychosis: Refining the Research Agenda for DSM-V provides an all-important summary of the latest research about the diagnosis and pathophysiology of psychosis. This volume gives the reader an inside look at how psychotic phenomena are represented in the current diagnostic system and how DSM-V might better address the needs of patients with such disorders.
The book presents a selection of papers reporting the proceedings of a conference titled "Deconstructing Psychosis" convened by the American Psychiatric Association (APA) in collaboration with the World Health Organization (WHO) and the U.S. National Institutes of Health (NIH). The conference was designed to be a key element in the multiphase research review process for the fifth revision of DSM. This book is one in a series of ten that reflects some of the most current and critical examinations of psychiatric disorders and psychotic syndromes. APA published the fourth edition of DSM in 1994 and a text revision in 2000. DSM-V is scheduled for publication in 2013.
Deconstructing
Psychosis: Refining the Research Agenda for DSM-V examines the
current evidence regarding the diagnosis and pathophysiology of common
psychotic syndromes including:
• Schizophrenia
• Bipolar disorder
• Major depressive
psychosis
• Substance-induced psychosis
It also addresses broad issues relating to diagnosis such as the ways in which psychosis cuts across multiple diagnostic categories. Beyond merely summarizing the current state of the science, the authors of these papers critique the current research and clinical evidence, and raise questions about gaps in our knowledge.
The book provides recommendations for the most promising areas of research in psychosis, which may lead to more refined treatments based on a better understanding of what biological and environmental factors contribute to its development and symptoms.
In the learned editors' selection of papers for inclusion in this volume, they have exhibited their conviction that DSM-V is a "living document" that will reflect the pace of progress in multiple areas, ranging from molecular genetics and brain imaging to social, behavioral, and anthropological science.
As a book on the narrowly defined topic of linking the classification of psychotic syndromes with their underlying pathophysiology and potential etiology, there is no other writing of comparable content available today.
Carol A. Tamminga, M.D., is a Professor of Psychiatry and Interim Chair of the Department of Psychiatry at the University of Texas Southwestern Medical Center in Dallas, Texas.
Paul J. Sirovatka, M.S., (1947-2007), was Director of Research Policy Analysis at the Division of Research and American Psychiatric Institute for Research and Education at the American Psychiatric Association.
Darrel A. Regier, M.D., M.P.H., is Executive Director of the American Psychiatric Institute for Research and Education and Director of the Division of Research at the American Psychiatric Association in Arlington, Virginia.
Jim van Os, M.D., Ph.D., is a Professor of Psychiatric Epidemiology in the Department of Psychiatry and Neuropsychology at the South Limburg Mental Health Research and Teaching Network, European Graduate School for Neuroscience at Maastricht University in Maastricht, The Netherlands; and Visiting Professor of Psychiatric Epidemiology in the Division of Psychological Medicine at the Institute of Psychiatry in London, England.
Contributors
Disclosure Statement
Foreword:
Rethinking Psychosis in DSM-V
introduction
Chapter 1. Deconstructing
Psychosis Conference February 2006: the Validity of Schizophrenia and
Alternative Approaches to the Classification of Psychosis
Chapter 2.
Biological, Life Course, and Cross-Cultural Studies All Point toward the
Value of Dimensional and Developmental Ratings in the Classification of
Psychosis
Chapter 3. Current Issues in the Classification of Psychotic
Major Depression
Chapter 4. Deconstructing Bipolar Disorder: A Critical
Review of Its Diagnostic Validity and A Proposal For DSM-V and
Icd-1
Chapter 5. DSM-V Research Agenda: Substance Abuse/Psychosis
Comorbidity
Chapter 6. The Genetic Deconstruction of
Psychosis
Chapter 7. How Should DSM-V Criteria for Schizophrenia include
Cognitive Impairment?
Chapter 8. Searching For Unique Endophenotypes for
Schizophrenia and Bipolar Disorder Within Neural Circuits and their
Molecular Regulatory Mechanisms
Chapter 9. Deconstructing Psychosis with
Human Brain Imaging
Chapter 10. Identifying Functional Neuroimaging
Biomarkers of Bipolar Disorder: toward DSM-V
Chapter 11. The
Neuropharmacology of Psychosis
index