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Clinical Manual of HIV Psychiatry
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07 March 2026
When the AIDS pandemic emerged in 1981, the diagnosis of AIDS was considered terminal. Over the four decades since then, advances in medicine have transformed HIV/AIDS into chronic and manageable—if still severe— condition. Despite this success, the annual incidence of HIV remains high, with 1.3 million new HIV infections worldwide and more than 30,000 in the United States.
The chapters in this illuminating and concise new manual suggest that this continued high incidence is driven at least in part a lack of a biopsychosocial approach to HIV prevention and care. The authors suggest that destigmatizing mental illness and integrating psychiatric aspects into multispecialty medical treatment, research, and public health policy are essential for the next level of meaningful progress in both prevention of HIV transmission and in the care of persons infected with and affected by HIV.
Drawing on the expertise of over 20 contributors, this book is organized into four key sections that examine
•
Psychiatric screening, risk assessment, consultation, and evaluation in HIV
care, including discussions of HIV testing, prevention, and stigma
•
Psychiatric illnesses associated with HIV infection, such as depressive,
anxiety, substance-related and addictive, and neurocognitive disorders
•
The clinical management of psychiatric comorbidities in HIV-positive
individuals, with attention to interactions between antiretrovirals and
psychotropics, palliative and end-of-life care, and ethical considerations
in HIV psychiatry
• The challenges of providing HIV care against the
backdrop of the COVID-19 pandemic and in resource-limited settings
Offering quick-reference tables and take-home points that distill key information, this clinically focused manual is an essential resource for infectious disease specialists, internists, pediatricians, psychiatrists, psychologists, nurses, and social workers who care for patients across the lifespan.
MEDICAL / Psychiatry / General
Luis F. Pereira, M.D., is an Assistant Professor of Psychiatry at Columbia University Irving Medical Center in New York City, New York.
Paulo Marcelo Gondim Sales, M.D., M.S. is a Consultation-Liaison Psychiatrist at Ally Psychiatry in Birmingham, Alabama, and Clinical Assistant Professor of Psychiatry at SUNY Downstate Health Sciences University in Brooklyn, New York.
John A. R. Grimaldi, M.D., is an Associate Psychiatrist at Brigham and Women's Hospital and Assistant Professor of Psychiatry at Harvard Medical School in Boston, Massachusetts.
James A. Bourgeois, O.D., M.D., is a Professor of Clinical Psychiatry at Department of Psychiatry and Behavioral Sciences, University of California, Davis, Medical Center in Sacramento, California.
Mary Ann Adler Cohen, M.D., is a Clinical Professor of Psychiatry in the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai in New York, New York.
Preface
Part 1: Testing, Prevention, and Assessment
for Psychiatric Disorders in HIV Care
Chapter 1. Psychiatric
Screening and Risk Assessment in HIV Care
Chapter 2: Consultation,
Assessment, and Evaluation in HIV Care
Chapter 3: HIV Testing and
Prevention
Chapter 4: Identifying and Addressing HIV Stigma
Part
2: Psychiatric Disorders Associated with HIV Infection
Chapter
5. Depressive Disorders and HIV Infection
Chapter 6. Anxiety Disorders
and HIV Infection
Chapter 7. Trauma and Stressor-Related Disorders and
HIV Infection
Chapter 8. Substance-Related and Addictive Disorders and
HIV Infection
Chapter 9. Neurocognitive Disorders and HIV
Infection
Chapter 10. Suicide and HIV Infection
Part 3: Clinical
Management of Psychiatric Multimorbidities in Persons with HIV
Infection
Chapter 11. Principles of HIV Treatment
Chapter
12. Antiretrovirals and Psychotropics: Drug Interactions and
Complications
Chapter 13. Integrated and Collaborative Care of
Psychiatric Multimorbidities in Persons with HIV Infection
Chapter 14.
Palliative and End-of-Life Care in Persons with HIV/AIDS
Chapter 15.
Ethical and Legal Challenges in HIV Psychiatry
Part 4: Global Aspects
of HIV Syndemics and Care
Chapter 16. HIV Syndemics: Addressing
Intersecting Health Challenges
Chapter 17. Pandemic Crossroads:
Providing HIV Care Amidst COVID-19
Chapter 18. Advancing HIV Care in
Resource-Limited Settings