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Clinical Decision Making in Psychiatry
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10 July 2025

Clinical Decision Making in Psychiatry is a practical guide developed to assist clinicians in navigating complex psychiatric decisions through structured, algorithm-driven frameworks.
The book offers a unique blend of evidence-based practices and real-world insights contributed by experienced clinicians.
Covering key challenges in psychiatric diagnosis, treatment planning, and long-term management (including treatment-resistant conditions and comorbidities), the text provides decision-making algorithms that present clear, step-by-step pathways for integrating clinical data with available treatment options.
Intended for a broad spectrum of mental health professionals, this resource aims to promote evidence-informed, flexible, and compassionate psychiatric care.
Samir Kumar Praharaj DPM MD
Professor, Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
Vikas Menon MD DNB
Professor, Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
Adarsh Tripathi MD MNAMS
Professor, King George's Medical University, Shahmeena Road, Chowk, Lucknow, Uttar Pradesh, India
Sai Krishna Tikka DPM MD
Associate Professor and In-charge Head of Department, Department of Psychiatry, AIIMS, Bibinagar, Hyderabad, Telangana, India
Chapter 1 - Assessment of Difficult-to-Treat Depression
Chapter 2 - Management of Difficult-to-Treat Depression
Chapter 3 - Pharmacological Management of Depression: How to Decide for Switching or Augmentation
Chapter 4 - How to Choose a Tricyclic Antidepressant
Chapter 5 - Rational Antidepressant Polypharmacy
Chapter 6 - How and When to Stop Treatment in Depressive Disorders
Chapter 7 - When and How to Use Ketamine in Clinical Practice?
Chapter 8 - Management of Difficult to Treat Generalized Anxiety Disorder
Chapter 9 - Management of Difficult to Treat Social Anxiety Disorder
Chapter 10 - Management of Difficult to Treat Somatic Symptom Disorder
Chapter 11 - Differential Diagnosis of Panic Attacks
Chapter 12 - Management of Difficult to Treat Panic Disorder
Chapter 13 - Differential Diagnoses of Obsessions
Chapter 14 - Management of Difficult-to-Treat Obsessive-Compulsive Disorder
Chapter 15 - Management of Comorbid Obsessive-Compulsive Disorder and Bipolar Disorder
Chapter 16 - Management of Difficult-to-Treat Mania
Chapter 17 - Management of Difficult-to-Treat Bipolar Depression
Chapter 18 - Management of Difficult-to-Treat Mixed Episode
Chapter 19 - Management of Rapid Cycling Bipolar Disorder
Chapter 20 - Antidepressant-induced Affective Switch
Chapter 21 - How to manage Premenstrual Mood Syndromes?
Chapter 22 - Approach to Diagnosis and Management of Insomnia
Chapter 23 - Assessment and Treatment of Sleep Disturbance in Mood and Anxiety Disorders
Chapter 24 - Management of Positive Symptoms in Schizophrenia
Chapter 25 - Treatment of Difficult-to-Treat Auditory Hallucination
Chapter 26 - Management of Negative Symptoms in Schizophrenia
Chapter 27 - Management of Aggression in Schizophrenia
Chapter 28 - Management of Catatonia
Chapter 29 - Management of Delusional Disorder
Chapter 30 - Rational Antipsychotic Polypharmacy: When, Where and How to Use?
Chapter 31 - How and When to Stop Treatment for Psychotic Disorders
Chapter 32 - Management of Nicotine Dependence Comorbid with Mood and Anxiety Disorders
Chapter 33 - Management of Nicotine Dependence Comorbid with Psychotic Disorders
Chapter 34 - Management of Cannabis Use Disorder Comorbid with Psychotic and Bipolar Disorder
Chapter 35 - Approach to Delirium - Diagnosis and Management
Chapter 36 - Differential Diagnosis of Dementia
Chapter 37 - Pharmacological Management of Cognitive Symptoms of Dementia
Chapter 38 - Pharmacological Management of Non-Cognitive Symptoms of Dementia
Chapter 39 - How to Assess Suicidal Behaviour?
Chapter 40 - Management of Suicidal Behaviour
Chapter 41 - Management of Acute Gastrointestinal Side Effects of Antidepressants
Chapter 42 - Management of Treatment-Emergent Sexual Dysfunction due to Antidepressants
Chapter 43 - Management of Antipsychotic-induced Sexual Dysfunction
Chapter 44 - Managing Renal Effects of Lithium Treatment
Chapter 45 - Management of Lithium-induced Cognitive Dysfunction
Chapter 46 - Management of Endocrine Effects of Lithium
Chapter 47 - Managing Weight Gain with Lithium Treatment
Chapter 48 - Management of Drug-induced Constipation
Chapter 49 - Management of Antipsychotic-induced Constipation
Chapter 50 - Management of Clozapine-induced Constipation
Chapter 51 - Management of Clozapine-induced Sialorrhea
Chapter 52 - Management of Clozapine-induced Tachycardia
Chapter 53 - Management of Drug-induced Akathisia
Chapter 54 - Management of Drug-induced Tardive Dyskinesia
Chapter 55 - Management of Drug-induced Hyperprolactinemia
Chapter 56 - Management of Drug-induced Sedation