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Written by expert contributors, this much-needed book emphasizes a quantitative and comprehensive perspective to explore the many dimensions of cellular Ca2+ signalling. Leading researchers in the field of calcium signaling present key aspects of this process in cells, starting with Ca2+ entry into the cell, its uptake from the cytosol by organelles, such as the endoplasmic reticulum and mitochondria, and the actions of Ca2+ in turn on a variety of important cellular regulatory processes. This research and reference text should prove useful to a wide readership, from students to researchers at many different levels, particularly in physiology, pharmacology, or biomedical engineering.
Key Features:
- Places a strong emphasis on Quantitative Biophysics
- Acts as a unique resource for state-or-the-art methods to study Ca2+ signals
- Includes emerging perspectives that link mechanistic insights to pathophysiological aspects of Ca2+ signalling
- Discusses a historical perspective on the development of key ideas in the field
Research in Dr. Satin’s laboratory is supported by NIH RO1 DK46409 and U01 DK127747.
Preface
Acknowledgement
Editor Biographies
List of contributors
1. Introduction
Part I Molecules mediating calcium influx
2. Calcium channel selectivity and permeation: function meets 3D structure
3. Structure and function of TRP channels
4. Glutamate-gated calcium currents in the central nervous system: structural determinants, regulatory mechanisms, and biological functions
Part II Calcium signaling on channels and other effectors
5. Monitoring the dynamics of calcium signaling effectors using genetically encoded fluorescent biosensors
6. Calcium-activated potassium channels
7. Calcium-activated chloride channels
Part III Physiological roles of calcium
8. Excitation–contraction coupling in skeletal muscle: fast Ca2+ signaling for muscle activation
9. Voltage-gated Ca2+ channels and excitation–secretion coupling at the synapse
10. Calcium signaling in context: case studies in endocrine cells
Part IV Calium channels in organelles
11. Characterization of endo-lysosomal cation channels using calcium imaging
12. The structural era of the mitochondrial calcium uniporter
Part V
13. Voltage-gated calcium channelopathies
14. Role of dysregulated calcium in neuropsychiatric diseases