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This book aims to critically discuss in detail, the fabrication of custom-made scaffolds and
all the biological, and physico-chemical aspects related with their adhesion, propagation,
proliferation and cell colonization processes, through in vitro assays and in vivo
implantation trials. This is to certify their therapeutic efficacy and potential use in clinical
applications. The authors are committed to providing appropriate information related to
the latest state-of-the-art in biomaterials technology, which is of paramount importance
for researchers and students in this area, which range from chemists, physicists, material
scientists and medical students. An attempt will be made to provide a sound balance
between materials science and their clinical health implications, thanks to the know-how
of the two main authors, which combines an experimental physicist expert in materials
science with a medical doctor (traumatologist) with more than 30 years of experience in
the field of biomaterials for clinical applications in regenerative medicine. With the
knowledge shared in the book, readers can make future choices as to which type of
materials will fit the most appropriately for their specific application
Key Features
Key Features
- Coverage of state-of-the art biomaterials appropriate for scientists, clinicians and students world-wide.
- Embedded multi-media related to 3D animations for reconstruction of bone defects from computerized tomography.
- Case studies will be included that are encompassed within appropriate videos.
- Animations for 3D reconstitution of bone defects from CT (Computerized Tomography) will be incorporated where appropriate.
- Extensive references will be included at the end of each chapter to enhance further study.
Price: £99.00
Pages: 350
Publisher: Institute of Physics Publishing
Imprint: Institute of Physics Publishing
Series: IPEM-IOP Series in Physics and Engineering in Medicine and Biology
Publication Date:
01 August 2023
ISBN: 9780750346474
Format: eBook
BISACs:
Preface
Table of Contents
Chapter 1: Overview and Historical Development of Biomaterials Science for
Regenerative Medicine
-Introduction and Historical Development
-Properties of Materials
-Some Background Concepts, Proteins, Cells, Tissues
-Functional Organization of an Organ Tissue
-Bone Graft and Bone Graft Substitutes. A Brief History
-Biology and Biomechanics of Bone Graft and Bone Substitutes
-Classes of Materials used in Medicine, Overview
-Biomaterials, Concepts
-Hydrogels, Natural Materials, Composites
-Polymers for Bone/Skin Graft Substitutes, Biopolymers as Biomaterials
-Classification, Applications in Medicine
-Bioceramics: Classification, Characterization, Bioactivity, Calcium Phosphate
-Ceramics for Bone/Skin Graft Substitutes
-Natural Bio-based Biomaterials
-Other Synthetic Materials for Bone/Skin Graft Substitutes
-Bioactive Materials and Composites
-Bioglasses and Bioactive Glass-Ceramics -Biometals
-Design of Nano and Biomaterials: Microfabrication, Modification and Functionlization
-3D Bioprinting
-Modalities and Biomaterials
-Bioink
-Bioinspired Materials for Biomedical Applications
-Characterization of Nano and Biomaterials
-Mechanical Properties
-Biologically Functional Materials
-Clinical Market for Tissue Engineering Products
-Cell-Based Therapies
-Cell Types and Sourcing
-Biology of the Natural Tissue Repair Process
-Host Reactions to Biomaterials and their Evaluation. Biological Response Local and
Systemic. Inflammation, Foreign Body Response. Biocompatibility of Materials. Systemic
Toxicity. Tumorigenesis
Chapter 2: Cellular Systems and Growth Factor-Based Systems for Tissue Engineering.
-Cellular Systems and Growth Factor-Based Systems for use as Bone Graft Substitute
-Tissue Engineering of Fracture Repair
-Engineered Cells in Scaffold for Heal Skin and Bone
-Bone Engineering with MSCs
-Cell-Based Approaches for Bone/Skin Graft Substitutes
-Allograft-Based Skin and Bone Graft Substitutes
-Growth Factor-Based Systems for use as Bone/Skin Substitutes
Chapter 3: Tissue Engineering, Clinical Applications in Medicine and Dentistry
-Principles of Tissue Engineering. Biomaterials in Tissue Engineering. Biomaterial-Adult
Stem Cell Association
-Tissue Engineering of Cartilage, Tendon, Meniscus, Intervertebral Disk
-Clinical Applications in Medicine and Dentistry
-Cardiovascular Applications
-Biomaterials as Substitutes for Bone Tissue
-Biomaterials as Carriers for Controlled Release of Molecules
-Dental Implants
-Ophthalmologic Applications
-Orthopaedic Applications
-Otorhinolaryngology
-Drug Delivery Systems
-Sutures
-Burn Dressing
-Bioelectrodes
-Biosensors
Chapter 4. Functional Tissue Engineering Testing, Regulation, Perspectives in Biomedical
Sciences
-Methodologies used in the Construction of Engineered Tissues
-Biomaterial Testing
-Case Studies
-In vitro Tests. Cell Cultures. Regulation of Cell Behaviour. Bioreactors
-In vivo assays. Animal models. Anatomopathological and micro-tomographic analysis
-Quality Control
-Functional Tissue Engineering
-Basic Information for the Successful Clinical use with Special Focus on Synthetic Graft
Substitutes (bone, skin, etc.)
-Can Tissue Engineering Really Help Patients? -Standardization and Regulation and Sanitary Control by the National Agency of Medicine
and Health Products
-Materials and Implant Approval
-Commercially Available Products, Medical Devices Inspired in Biomaterials
-Perspectives and Possibilities in Biomedical Science
Chapter 5: An Introduction to 3D Biofabrication and Translational Medicine
-Software for Biofabrication
-Medical Images Acquisition: (CT, MRI, 3D Ultrasound)
-Reconstitution and Optimization of a 3D Model: Workflow from a Patient Defect to the
Printed Object
-Examples of Clinical Conditions
Glossary
References