This chapter reviews the recent commercialization of microbial bioprotectant products containing bacteria, fungi, yeast and bacteriophages for the control of plant diseases. The chapter also summarizes recent development activities of new bioprotectant products based on microorganisms or their metabolites, including induced resistance products, single domain antibody proteins produced by microorganisms, and protozoans (amoebae). Production, mainly by submerged fermentation, and formulation processes of microbial bioprotectants will be discussed. Key factors influencing the fermentation, formulation and the scale up for industrial production of such microorganism as bioprotectant products are also addressed, including stability and viability of the active substances produced by liquid fermentation processes.