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Formerly known as Non Alcoholic Fatty Liver Disease, Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) is a long-lasting liver condition caused by having too much fat in the liver. It is closely linked with being overweight, as well as conditions such a Type 2 diabetes and heart and circulatory disease.
Designed for everyday clinical use, this evidence-based guide covers the full spectrum of MASLD, from its historical evolution and pathophysiology, to diagnosis, treatment, and long-term management.
It integrates the latest guidelines and therapies, including emerging agents such as resmetirom and GLP-1 agonists, and provides practical tools such as non-invasive diagnostics (FIB-4, elastography, MRI-PDFF), risk stratification algorithms, and detailed approaches for special populations including children, pregnant women, and those with cirrhosis or hepatocellular carcinoma.
Emphasising a multidisciplinary and personalised care model, the book also explores public health strategies, cost-effective screening, and healthcare implications.
Shambo Samrat Samajdar MD DM (Clinical Pharmacology) PG Dip Endo & Diabetes (RCP) Diploma in Allergy Asthma & Immunology Fellowship in Respiratory and Critical Care (WBUHS)
Independent Clinical Pharmacologist and Consultant, Diabetes and Allergy-Asthma Therapeutics Specialty Clinic, Kolkata, West Bengal, India
Rupak Chatterjee MD (Tropical Medicine)
Nodal Officer - Vector Borne Diseases; Senior Resident, Bijoygarh State General Hospital, Kolkata, West Bengal, India
Sanjay Bandyopadhyay MD DNB DM (Gastro) MNAMS FACP (USA) FRCP (Glasgow) FRCP (London)
Director, Kolkata Gastro Care Foundation, Kolkata; Senior Consultant, Department of Gastroenterology, ILS Dumdum Hospital, Kolkata, India
Shashank R Joshi MD DM FICP FACP (USA) FACE (USA) FRCP (London, Glasgow and Edinburgh) (Padma Shri Awardee )
Chair, International Diabetes Federation Southeast Asia; Endocrinologist, Joshi Clinic, Lilavati Hospital, Mumbai, Maharashtra, India
Section I - Introduction and Background
Chapter 1 - Historical Perspective: From NAFLD to MASLD
Chapter 2 - Epidemiology of MASLD
Chapter 3 - Pathophysiology
Chapter 4 - Clinical Significance
Section II - Diagnosis of MASLD
Chapter 5 - Diagnostic Criteria
Chapter 6 - Non-Invasive Diagnostic Tools
Chapter 7 - Advanced Imaging Techniques
Chapter 8 - Screening in High-Risk Populations
Section III - Risk Stratification and Comorbidities
Chapter 9 - Liver Fibrosis Assessment
Chapter 10 - Cardiovascular Disease in MASLD
Chapter 11 - Type 2 Diabetes and MASLD
Chapter 12 - Other Comorbidities
Section IV - Management and Treatment
Chapter 13 - Lifestyle Modifications
Chapter 14 - Pharmacological Therapies
Chapter 15 - Multidisciplinary Care Models
Section V - Advanced and Special Considerations
Chapter 16 - MASLD in Pediatrics and Adolescents
Chapter 17 - MASLD and Pregnancy
Chapter 18 - Cirrhosis and Hepatocellular Carcinoma (HCC)
Chapter 19 - Surgical and Interventional Approaches
Section VI-Future Directions
Chapter 20 - Advances in Research
Chapter 21 - Health Policy and Public Health Implications
Chapter 22 - Personalized Medicine in MASLD