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This new edition of The American Psychiatric Association Publishing Textbook of Mood Disorders is a systematic and painstaking reconceptualization of its predecessor. Under new editorial direction and with a revised roster of expert contributors, the second edition is an utterly current, clinically competent, and comprehensive text that will become an instant classic. The book is structured for learning and easy reference, moving deftly from symptomatology and epidemiology to pathogenesis and on to somatic interventions, cognitive-behavioral interventions, and psychotherapy. The latest science on genetics and epigenetics, brain imaging, and neurobiology are also examined in depth. Critically important to the clinician is the section on management of mood disorders, which provides treatment guidelines for major depressive disorder and bipolar disorder, as well as information on understanding, and preventing, suicide in children, adolescents, and adults. Finally, perspectives are offered on depression among women, children, and geriatric patients, as well as on depression across cultures. Practicing psychiatrists, residents, and students alike will benefit from the book's inclusive coverage.
Topics new to this edition include the following:
• Treatment-resistant depression—its definition and approaches to its
treatment—is addressed in a dedicated chapter that covers diagnostic
accuracy, pseudoresistance, comorbidity, pharmacological management,
adjunctive strategies, psychotherapy, neuromodulation, and novel and
experimental therapies.
• Investigational agents, most notably ketamine
and its relatives, constitute an exciting frontier in the treatment of mood
disorders, and the clinical application, routes of delivery, dosing, risks,
and clinical trials are explored in a dedicated chapter that is both
rigorous and thorough.
• There is compelling evidence that childhood
maltreatment (defined as exposure to emotional, physical, and sexual abuse
and neglect before the age of 18 years) is a prominent risk factor for the
development of mood disorders as well as for a pernicious course and poor
treatment response in mood disorders. These findings, as well as the
underlying neurobiological and environmental interactions that may
contribute to the development of mood disorders, are examined thoroughly and
thoughtfully.
• As our understanding of immune function in mood
disorders has grown, psychoneuroimmunology has emerged as a focus of study
likely to make major contributions to clinical practice in the coming
decades. The book updates readers on this promising area of research.
Over the last decade, depression has emerged as the leading cause of disability worldwide, with significant attendant morbidity and mortality. The American Psychiatric Association Publishing Textbook of Mood Disorders equips clinicians and trainees with the knowledge they need to alleviate suffering in their patients with mood disorders.
This second edition is a comprehensive, detailed, up-to-date reference regarding the current understanding of mood disorders, written by experts in the field. It should be on the bookshelves of those who are involved in the treatment of these individuals.
— Michael Easton, MD
Charles B. Nemeroff, M.D., Ph.D., is the Matthew P. Nemeroff Professor and Chair of the Department of Psychiatry & Behavioral Sciences at the University of Texas, Austin, Dell Medical School.
Natalie Rasgon, M.D., Ph.D., is a Professor in the Department of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology at Stanford University School of Medicine and is also the Director of the Stanford Center for Neuroscience in Women's Health and the Associate Dean of Academic Affairs.
Alan F. Schatzberg, M.D., is Kenneth T. Norris, Jr., Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California, where from 1991 to 2010 he was also the Chair of Psychiatry. He is currently Director of the Stanford Mood Disorders Center.
Stephen M. Strakowski, M.D., is Vice Dean of Research and Associate Vice President, Regional Mental Health, at the Dell Medical School, University of Texas at Austin. He is also Professor of Psychiatry & Behavioral Sciences, Psychology, and Educational Psychology at the University of Texas, Austin.
Contributors
Preface
Part I: Symptomatology and
Epidemiology
Chapter 1. Historical Aspects of Mood
Disorders
Chapter 2. Classifications of Mood Disorders
Chapter 3.
The Epidemiology and Burdens of Mood Disorders
Chapter 4. Rating Scales
and Structured Diagnostic Interviews for Mood Disorders
Part II:
Pathogenesis of Mood Disorders
Chapter 5. Neurochemistry of Mood
Disorders
Chapter 6. Psychoneuroendocrinology of Mood
Disorders
Chapter 7. Role of the Immune System in Mood
Disorders
Chapter 8. Evolutionary Contributions to the Understanding of
Mood and Mood Disorders
Part III: Investigating Mood
Disorders
Chapter 9. Anatomical Pathology
Chapter 10. Molecular
and Cellular Neurobiology of Severe Mood Disorders
Chapter 11. Brain
Imaging
Chapter 12. Review of Mood Disorder Genetics
Chapter 13.
Epigenetics of Mood Disorders
Part IV: Somatic Interventions for Mood
Disorders
Chapter 14. Tricyclics, Tetracyclics, and Monoamine
Oxidase Inhibitors
Chapter 15. Selective Serotonin Reuptake Inhibitors,
Serotonin-Norepinephrine Reuptake Inhibitors, and Other Related
Antidepressants
Chapter 16. Lithium and Mood Stabilizers
Chapter 17.
Use of Antipsychotic Medications in Mood Disorders
Chapter 18.
Electroconvulsive Therapy in the Treatment of Mood Disorders
Chapter 19.
Transcranial Magnetic Stimulation for Major Depressive Disorder
Chapter
20. Vagus Nerve Stimulation and Deep Brain Stimulation
Chapter 21. Other
Antidepressants: Trazadone, Mirtazapine, Bupropion
Chapter 22. Ketamine
and Other Investigational Agents
Part V: Psychotherapy of Mood
Disorders
Chapter 23. Cognitive and Behavior Therapies for Major
Depressive Disorder and Persistent Depressive Disorder
Chapter 24.
Interpersonal Psychotherapy for Major Depressive Disorder and Persistent
Depressive Disorder
Chapter 25. Psychoanalytic and Psychodynamic
Psychotherapy for Depression and Dysthymia
Chapter 26. Psychotherapeutic
Approaches to Bipolar Disorder
Chapter 27. Psychotherapy for Depression
in Children and Adolescents
Part VI: Integrative Management of Mood
Disorders
Chapter 28. Practice Guidelines for Major Depressive
Disorder
Chapter 29. Guidelines for Treatment of Bipolar
Disorder
Chapter 30. Understanding and Preventing Suicide
Chapter
31. Suicide in Children and Adolescents
Chapter 32. Combination
Strategies for the Pharmacological Treatment of Major Depressive
Disorder
Chapter 33. Management of Treatment-Resistant
Depression
Part VII: Subtypes of Mood Disorders
Chapter
34. Seasonal Affective Disorder and Light Therapy for Mood
Disorders
Chapter 35. Atypical Depression, Dysthymia, and
Cyclothymia
Chapter 36. Major Depressive Disorder With Psychotic
Features
Chapter 37. Pediatric Mood Disorders
Chapter 38. Geriatric
Mood Disorders
Part VIII: Additional Perspectives on Mood
Disorder
Chapter 39. Depression in Primary Care
Chapter 40.
Depression in Medical Illness
Chapter 41. Mood Disorders and Substance
Use
Chapter 42. Depression in Women
Chapter 43. Depression Across
Cultures: An Ecosocial Approach
Chapter 44. Mood Disorders and
Sleep
Chapter 45. Childhood Maltreatment and Mood
Disorders
Index