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In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer.
This completely revised second edition of is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.
Preface
About the author
Introduction
1 Initiation of a neoplasm or tumor
2 Inflammation and cancer
3 Cellular stiffness and deformability
4 Cell–cell and cell–matrix adhesion strength, local cell stiffness and forces
5 Cell surface tension, the mobility of cell surface receptors and their location in specific regions
6 Cytoskeletal remodeling dynamics
7 Actin filamen during matrix invasion
8 Intermediate filaments during matrix invasion
9 Microtubules during migration and matrix invasion
10 Nuclear deformability during migration and matrix invasion
11 The mechanical and structural properties of the microenvironment
12 The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion
13 The active role of the tumor stroma in regulating cell invasion
14 The role of endothelial cell-cell adhesions
15 The mechanical properties of endothelial cells altered by aggressive cancer cells
16 The role of macrophages during cancer cell transendothelial migration