Organic potato cultivation requires a whole system perspective, with particular focus on rotation design. Producing organic potatoes relies strongly on indirect, preventive and long-term strategic measures for both plant nutrition and plant protection. This chapter examines all aspects of the process of cultivating organic potatoes, including rotation and diversification, breeding, seed potatoes, planting, tillage, weed control, nutrient management, soil fertility and irrigation. The chapter also describes the main diseases and pests of potatoes and organic methods of disease and pest regulation.