Consumer concerns about food safety have been translated into policy in consuming countries, including pesticide residues in cocoa. Such policy changes have an impact on cocoa producers and other supply chain stakeholders, as they have to comply with legislation or risk losing lucrative markets. Consequently, development and implementation of best practice for pesticide use is critical, but major challenges exist in-country. The chapter provides an overview of pesticide use in cocoa-producing countries and the challenge of improving pesticide regulation, before moving on to consider the development of best practice for pesticide use. The chapter provides detailed case studies on establishing baselines, promoting awareness and developing a holistic approach. Finally, the chapter looks ahead to future research trends and provides guidance for further reading in this area.