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Collagen has proved to be a safe and effective biomedical material. Clinicians have used collagen-based devices in a wide range of applications with successful patient outcomes. This book gives an understanding of how present devices work, how they could be improved, and the development of new devices where a knowledge of collagen structure, chemistry and biology is required. The purification of collagen materials and the fabrication of a range of collagen products and their applications are covered within. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students.
Preface
I Introduction
1 Introduction
II The Structure and Biochemistry of Collagen
2 The structure of collagen
3 Biosynthesis and biodegradation of collagen
4 Collagen Assemblies
5 Tissue Arrangement
6 Collagen stability
7 Interactions
III The Production of Collagen-based Biomaterials
8 Production of tissue derived collagens
9 Production of recombinant collagens
10 Evaluation of the Quality of Collagen Preparations
11 Fabrication of biomedical products
12 Chemical Modifications
IV Applications of collagen in medical products
13 Applications for intact tissue collagen
14 Applications for purified collagen
15 Applications of biosynthetic materials
16 Collagen applications in tissue engineering and regenerative medicine
17 Coating of biomedical materials with collagen
18 Composites of collagen with other materials
V Conclusions
19 Concluding remarks